Genome Stability and Human Diseases

Genome Stability and Human Diseases
(Subcellular Biochemistry)
By Heinz Peter Nasheuer

  • Publisher: Springer
  • Number Of Pages: 340
  • Publication Date: 2010-01-01
  • ISBN-10 / ASIN: 9048134706
  • ISBN-13 / EAN: 9789048134700

Product Description:

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting bottlenecks in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.
This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Essential Physiological Biochemistry: An Organ-Based Approach

Essential Physiological Biochemistry: An Organ-Based Approach
By Stephen Reed

  • Publisher: Wiley
  • Number Of Pages: 342
  • Publication Date: 2010-02-15
  • ISBN-10 / ASIN: 0470026367
  • ISBN-13 / EAN: 9780470026366

Product Description:

This text provides a fresh, accessible introduction to human metabolism that shows how the physiological actions of selected organs can be explained by their particular biochemical processes.
Focusing on metabolic integration, rather than pathways, this book opens with three introductory chapters that explore the principles of metabolism and its control before moving onto themed chapters that investigate liver, communication systems (endocrine and neurological), blood and vascular system, muscle and adipose tissue and renal biochemistry.
Targeted at non-biochemistry majors who need to get to grips with key biochemical concepts and ideas, this textbook is an essential guide for all undergraduate biomedical science, sports science, nutrition and other allied health students.
Key features:
  • A fresh, accessible primer that adopts a unique, organ-system based approach to human metabolism.
  • Assumes only a basic understanding of chemistry.
  • Chapters are arranged specifically to enable readers to grasp key concepts and to aid understanding.
  • Some chapters include Case Notes, illustrating key aspects of metabolism in cells, tissues and organs

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Schaum's Outline of Biochemistry, Third Edition

Schaum’s Outline of Biochemistry, Third Edition
(Schaum’s Outline Series)
By Philip Kuchel, Audrey Bersten, Simon Easterbrook-Smith, Vanessa Gysbers, Arnold Hunt, Alan Jones, M. Dan Montague, Reg O’Brien, G.B. Ralston, Michael Slaytor, Michael Thomas, R. Wake

  • Publisher: McGraw-Hill
  • Number Of Pages: 528
  • Publication Date: 2009-07-20
  • ISBN-10 / ASIN: 0071472274
  • ISBN-13 / EAN: 9780071472272

Product Description:

Confusing Textbooks? Missed Lectures? Not Enough Time?
Fortunately for you, there’s Schaum’s Outlines. More than 40 million students have trusted Schaum’s to help them succeed in the classroom and on exams. Schaum’s is the key to faster learning and higher grades in every subject. Each Outline presents all the essential course information in an easy-to-follow, topic-by-topic format. You also get hundreds of examples, solved problems, and practice exercises to test your skills.
This Schaum’s Outline gives you:

  • Practice problems with full explanations that reinforce knowledge
  • Coverage of the most up-to-date developments in your course field
  • In-depth review of practices and applications
Fully compatible with your classroom text, Schaum’s highlights all the important facts you need to know. Use Schaum’s to shorten your study time-and get your best test scores!
Schaum’s Outlines–Problem Solved.

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Analytical Chemistry

Analytical Chemistry
By Gary D. Christian

  • Publisher: Wiley
  • Number Of Pages: 848
  • Publication Date: 2003-03-14
  • ISBN-10 / ASIN: 0471214728
  • ISBN-13 / EAN: 9780471214724

Product Description:

This text is designed for the one-term Quantitative Analysis/Analytical Chemisty course for students majoring in Chemistry and related fields. It deals with principles and techniques of quantitative analysis. Examples of analytical techniques are drawn from such areas as life sciences, clinical chemistry, air and water pollution, and industrial analyses. The Sixth Edition is extensively revised and updated with a more modern flavor and a new, two-color design.

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Oxford Dictionary of Biochemistry and Molecular Biology-2nd ED

Oxford Dictionary of Biochemistry and Molecular Biology
By Teresa Atwood, Peter Campbell, Howard Parish, Tony Smith, John Stirling, Frank Vella

  • Publisher: Oxford University Press, USA
  • Number Of Pages: 736
  • Publication Date: 2006-08-24
  • ISBN-10 / ASIN: 0198529171
  • ISBN-13 / EAN: 9780198529170
  • Binding: Hardcover

Product Description:
The Oxford Dictionary of Biochemistry and Molecular Biology provides a comprehensive survey of current biochemistry and molecular biology. Over the last few years, the language of Biochemistry and Molecular Biology has expanded enormously to the extent that few scientists can expect to be familiar with all aspects of it. This is partly due to the Genome projects and the successive -omics projects which have provided comprehensive information about genes, the functions of gene products, and cellular processes. At the same time, terms from other subject areas appear increasingly in the biochemical literature. The popular Dictionary has been comprehensively reviewed and updated to include many important new concepts and words. The entries are short but informative, providing up-to-date information on a broad range of topics, including definitions for selected terms from Bioinformatics, Biophysics, Cell Biology, Chemistry, Genetics, Immunology, Mathematics, Microbiology, Pharmacology, Systems Biology, and Toxicology. There are over 21,000 main entries, which give details of biochemical substances and the processes in which they are involved, define methods and concepts in molecular biology, and give definitions of biochemical symbols and abbreviations. It points out pitfalls where terms are often confused. It explains the precise syntax of biochemical terms, such as Greek letters and other formatting, which are lost when searching the Internet. In addition the dictionary is illustrated with over 900 chemical structures.
The Oxford Dictionary of Biochemistry and Molecular Biology will serve as an invaluable reference for biochemists and molecular biologists seeking information outside their own fields, and for those wishing to revisit fundamental principles.

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Coordinated Activity in the Brain

Coordinated Activity in the Brain: Measurements and Relevance to Brain Function and Behavior
(Springer Series in Computational Neuroscience)
By Jose Luis Perez Velazquez, Richard Wennberg

  • Publisher: Springer
  • Number Of Pages: 265
  • Publication Date: 2009-06-11
  • ISBN-10 / ASIN: 038793796X
  • ISBN-13 / EAN: 9780387937960

Product Description:

Increasing interest in the study of coordinated activity of brain cell ensembles reflects the current conceptualization of brain information processing and cognition. It is thought that cognitive processes involve not only serial stages of sensory signal processing, but also massive parallel information processing circuitries, and therefore it is the coordinated activity of neuronal networks of brains that give rise to cognition and consciousness in general. While the concepts and techniques to measure synchronization are relatively well characterized and developed in the mathematics and physics community, the measurement of coordinated activity derived from brain signals is not a trivial task, and is currently a subject of debate. Coordinated Activity in the Brain: Measurements and Relevance to Brain Function and Behavior addresses conceptual and methodological limitations, as well as advantages, in the assessment of cellular coordinated activity from neurophysiological recordings. The book offers a broad overview of the field for investigators working in a variety of disciplines (neuroscience, biophysics, mathematics, physics, neurology, neurosurgery, psychology, biomedical engineering, computer science/computational biology), and introduces future trends for understanding brain activity and its relation to cognition and pathologies. This work will be valuable to professional investigators and clinicians, graduate and post-graduate students in related fields of neuroscience and biophysics, and to anyone interested in signal analysis techniques for studying brain function.

About the Editors:
J. L. Perez Velazquez was born in Zaragoza, Spain, and received the degree of ‘Licenciado’ in Chemistry (Biochemistry, universities of Zaragoza and Complutense of Madrid), and a PhD degree in 1992 from the Department of Molecular Physiology and Biophysics at Baylor College of Medicine (Houston), homologated to Doctorate in Chemistry by the Spanish Ministry of Culture in 1997. He is an Associate Scientist in the Neuroscience and Mental Health Programme and the Brain and Behaviour Centre at the Hospital For Sick Children in Toronto, and an Associate Professor at the University of Toronto.
Richard Wennberg was born in Vancouver, Canada. He obtained his medical degree from the University of British Columbia in 1990 and completed a neurology residency at McGill University in 1994, followed by a fellowship in electroencephalography at the Montreal Neurological Institute. He is Director of the clinical neurophysiology laboratory at the University Health Network, Toronto Western Hospital; Associate professor of Medicine at the University of Toronto; Chair of the Royal College of Physicians and Surgeons of Canada examination board in neurology, and President of the Canadian League Against Epilepsy.

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Advanced Practical Medicinal Chemistry

Advanced Practical Medicinal Chemistry

Ashutosh Kar “Advanced Practical Medicinal Chemistry”
New Age International (P) Ltd. | 2004 | ISBN: 8122415393 | 332 pages | PDF | 2,5 MB

The present compendium on Advanced Practical Medicinal Chemistry is designed specifically to serve as a text-***-reference book not only intended for the advanced undergraduate and graduate students of Pharmacy specializing in pharmaceutical chemistry but also for the bulk-drug industrial researchers and academics who work intimately with medicinal compounds. It mainly comprises of four comprehensive chapters. First chapter is entirely devoted to Safety in Chemical Laboratory, which is an absolute must for each medicinal chemist. Second chapter is on Drug Synthesis and concentrates on three vital aspects, namely : conceptualization of a synthesis, reaction variants, and stereochemistry. Third chapter exclusively deals with Performing the Reactions and entails the wide range of latest laboratory techniques used in a good chemical laboratory to facilitate synthesis of drugs.

Fourth chapter is particularly focused and earmarked to Synthesis of Medicinal Compounds, and essentially include various cardinal aspects, such as :types of chemical reactions, organic name reactions (ONRs), and selected medicinal compounds. A galaxy of eighty carefully chosen medicinal compounds have been presented in an original unique style comprising of: chemical structure, synonym (s)/chemical name(s) theory chemicals required procedure precautions recrystallization theoretical yield/practical yield physical parameters uses, and questions for viva-voce.

It is hoped that Advanced Practical Medicinal Chemistry would certainly help to bridge existing gap and fill up the long needed vacuum in the synthesis of drugs in pharmaceutical chemistry departments, academics and bulk-drug industries, and may provide the basis for meaningful productive group discussions of synthetic problems on a broader perspective.

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Clinical Chemistry

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Electrophoresis: Theory, Techniques, and Biochemical and Clinical Applications

Electrophoresis: Theory, Techniques, and Biochemical and Clinical Applications
(Monographs on Physical Biochemistry)
By Anthony T. Andrews

  • Publisher: Oxford University Press, USA
  • Number Of Pages: 450
  • Publication Date: 1986-04-24
  • ISBN-10 / ASIN: 0198546327
  • ISBN-13 / EAN: 9780198546320

Product Description:

Electrophoretic methods play a crucial role in biochemical analysis and in many diverse fields, food science and genetic engineering among them. This new, extensively revised and up-dated edition covers all types of electrophoresis and focuses on recent techniques and developments. The book emphasizes forms of gel electrophoresis, specifically those methods based on polyacrylamide gels. The author has added two new chapters, on isotachophoresis and on two-dimensional electrophoresis, and has expanded the material on blotting techniques, isoelectric focusing in beds of granulated gel, and gel electrophoresis in organic solvents. From reviews of the first edition: “Dr. Andrews is to be congratulated on providing under one cover, succinct, clear, and practical descriptions of electrophoresis.” –Nature. “A must for biologists, immunologists, microbiologists, and any scientist interested in modern separation science.” –Journal of the American Chemical Society.

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Medical Biochemistry ~ Revised Second Edition

Medical Biochemistry ~ Revised Second Edition
by: N. Mallikarjuna Rao.

Copyright 2006, 2002 New Age International (P) Ltd., Publishers
Published by New Age International (P) Ltd., Publishers

PREFACE TO THE SECOND EDITION
I attempted to provide essential information on molecular basis of health and disease
that is mainly related to life of surviving cell(s) in the first edition of the book. However life
cycle of cell(s) includes cell(s) birth and cell(s) death apart from survival. For the last couple
of years these frontier areas are advancing rapidly which is viewed by many as good sign
for development of :
(a) new therapy or therapeutics for cancer
(b) immortalized cells.
The latter fuels growth of biotechnology and pharmaceutical industries also. Hence, in
the second edition two chapters1. Biochemistry of cell cycle (cell birth) 2. Biochemistry of
apoptosis (cell death) are added.
As living organisms evolved from simple unicellular to highly complex multicellular
mammals, several new systems and organs were developed. For example, blood which acts
as vehicle or communication between various locations of body, immune system which
protects body from intruders or foreign organisms.
Parkinsonism, psychosis, depression, Schizophrenia, loss of taste and olfaction are due
to disturbances in nervous, taste and olfactory systems. Various organs present in body
perform several organ specific functions which are essential for life. If functions of these
organs are disturbed, diseases in which may culminate in death. So, in this edition biochemistry
of blood including immune response in Chapter-32; molecular and cellular mechanism of
learning, memory, behaviour, taste and olfactory in biochemical communications Chapter;
tests, procedures that are done in hospital biochemistry laboratory to assess functions of
liver, kidney in Chapter-33 and thyroid in Chapter-29 are detailed.
Depending on disease a particular constituent of blood is either elevated or lowered.
Diagnosis and prognosis of disease usually involves detection and measurement of various
blood constituents in hospital biochemistry laboratory. Therefore advanced techniques like
high performance liquid chromatography (HPLC), affinity chromatography, and general
techniques like centrifugation and dialysis, instruments from spectrophotometer to auto
analyzer and methods used for detection and quantitation of blood constituents like
carbohydrates, proteins, lipids, nucleic acids, enzymes, electrolytes etc., in health and disease
are detailed in Chapter-34.
Humans and other mammals are able to remove waste products, toxins, foreign
compounds from blood and organs in the form of urine. In disease, composition of urine
varies from that of healthy state. So, detection, quantitation of various constituents of urine
is carried out in hospital biochemistry laboratory to confirm diagnosis of diseases. In Chapter
34, methods for detection and estimation of urine constituent under normal and diseased
conditions are also detailed.
Most striking feature in this edition of the book is inclusion of biochemical aspects of
diseases or disease causing organisms common to tropical countries like malaria, tuberculosis,
peptic ulcer or gastritis, pneumonia, leishmaniasis, giardiasis, trypanosomiasis etc. Since
most of the organisms are developing resistance to the existing drugs, there is need for
development of new drugs which requires thorough biochemical knowledge of these diseases
as well as disease causing organisms. Apart from adding new chapters, all existing chapters
have been updated by adding new subject matter. References of each chapter updated by
including reviews, books, research articles etc. Further, number of unsolved problems have
been increased in most of the chapters.
I hope this edition will be well received by teachers and students of various medical,
dental, pharmacy, biotechnology, physiotherapy, medical laboratory technology, biomedical
engineering, life sciences under graduate and post graduate courses, Suggestions or comments
from teachers and students are welcome. I am grateful to Sri. R.K. Gupta, Chairman; Sri
Saumya Gupta, Managing Director of New Age International, New Delhi, for publishing
second edition.
N. MALLIKARJUNA RAO

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